Hes 和牙周疾病相關的研究內容

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Effects of cross-linking agents on hydroxyproline release and root caries lesion size: Systematic review and network meta-analysis of in vitro studies.

Monici Silva I, Barbosa CB, Cena JA, Ribeiro E, Garcia FCP, Stefani CM, Dame-Teixeira N.

Eur J Oral Sci. 2024 Dec;132(6):e13028. doi: 10.1111/eos.13028. Epub 2024 Nov 23.

PMID: 39579122 Review.

The network meta-analysis for lesion depth involved 284 samples across 36 comparisons and ranked cross-linking agents in terms of their caries lesion depth-reducing effect (from best to worst): naringin > quercetin > riboflavin > proanthocyanidins > hesperidin …

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Flavonoids modulate regenerative-related cellular events in LPS-challenged dental pulp cells.

Mendes Soares IP, Anselmi C, Ribeiro RAO, Mota RLM, Pires MLBA, Fernandes LO, de Souza Costa CA, Hebling J.

J Dent. 2024 Dec;151:105424. doi: 10.1016/j.jdent.2024.105424. Epub 2024 Oct 18.

PMID: 39427960

3

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Neohesperidin exerts subtle yet comprehensive regulation of mouse dental papilla cell-23 in vitro.

Zhang S, Guan J, Lv J, Dong X, Li R, Wang Y, Jin XA.

Arch Oral Biol. 2024 Nov;167:106055. doi: 10.1016/j.archoralbio.2024.106055. Epub 2024 Jul 24.

PMID: 39067325

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Exploring the role of flavonoids in caries-affected dentin adhesion: A comprehensive scoping review.

Beckman CKC, de Lima Costa T, Puppin-Rontani RM, de Castilho ARF.

Arch Oral Biol. 2024 Jun;162:105942. doi: 10.1016/j.archoralbio.2024.105942. Epub 2024 Mar 3.

PMID: 38452415 Review.

RESULTS: The review analyzed eight different flavonoids (hesperidin, galardin, proanthocyanidin, genipin, quercetin, naringin, epigallocatechin-3-gallate, and other catechins subtypes) used as pretreatment or loaded into adhesive systems, primers, and phosphoric acid. ...

5

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Iron overload induced submandibular glands toxicity in gamma irradiated rats with possible mitigation by hesperidin and rutin.

Ahmed SF, El-Maghraby EMF, Rashad MM, Bashir DW.

BMC Pharmacol Toxicol. 2024 Feb 27;25(1):22. doi: 10.1186/s40360-024-00744-8.

PMID: 38414079 Free PMC article.

VEGF and NF-kappaB were also significantly overexpressed. Hesperidin and rutin cotreatment generated partial recovery as indicated by significant upregulation of Nrf-2, SOD and BRCA1 and considerable downregulation of TNF-alpha, IL-1beta, VEGF, PIK3ca, AKT, and mTOR. ...CO …

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Atrophy and Inflammatory Changes in Salivary Glands Induced by Oxidative Stress after Exposure to Drugs and Other Chemical Substances: A Systematic Review.

Ungureanu LB, Grădinaru I, Ghiciuc CM, Amălinei C, Gelețu GL, Petrovici CG, Stănescu RȘ.

Medicina (Kaunas). 2023 Sep 21;59(9):1692. doi: 10.3390/medicina59091692.

PMID: 37763811 Free PMC article. Review.

There are many antioxidants but only a few were evaluated regarding the effects on salivary glands in animal studies, such as hesperidin and selenium, which can reverse the damage induced by cyclophosphamide; 10-dehydrogingerdione (10-DHGD), a compound extracted from ginge …

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Effect of Hesperidin on Barrier Function and Reactive Oxygen Species Production in an Oral Epithelial Cell Model, and on Secretion of Macrophage-Derived Inflammatory Mediators during Porphyromonas gingivalis Infection.

Maquera-Huacho PM, Spolidorio DP, Manthey J, Grenier D.

Int J Mol Sci. 2023 Jun 20;24(12):10389. doi: 10.3390/ijms241210389.

PMID: 37373533 Free PMC article.

New therapies using flavonoids, such as hesperidin, are being studied, and their promising properties have been highlighted. The aim of this study was to evaluate the effect of hesperidin on the epithelial barrier function, reactive oxygen species (ROS) production, …

8

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Evaluation of the remineralization and antibacterial effect of natural versus synthetic materials on deep carious dentin: A randomized controlled trial.

Anani H, Elasser D, Niazy M, Jamil W, Elsharkawy D.

Dent Med Probl. 2023 Jan-Mar;60(1):87-97. doi: 10.17219/dmp/147075.

PMID: 37023336 Free article. Clinical Trial.

OBJECTIVES: The aim of the present study was to explore the remineralization and antibacterial effect of natural (propolis, hesperidin) vs. synthetic (silver diamine fluoride (SDF)) agents on deep carious dentin. ...CONCLUSIONS: In comparison with SDF, propolis and hesp …

9

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Synthesis, characterization, and evaluation of Hesperetin nanocrystals for regenerative dentistry.

Alipour M, Sharifi S, Samiei M, Shahi S, Aghazadeh M, Dizaj SM.

Sci Rep. 2023 Feb 6;13(1):2076. doi: 10.1038/s41598-023-28267-y.

PMID: 36746996 Free PMC article.

Hesperetin (HS), a metabolite of hesperidin, is a polyphenolic component of citrus fruits. This ingredient has a potential role in bone strength and the osteogenic differentiation. ...

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Protective effects of hesperidin in cyclophosphamide-induced parotid toxicity in rats.

Mostafa OAA, Ibrahim F, Borai E.

Sci Rep. 2023 Jan 4;13(1):158. doi: 10.1038/s41598-022-26881-w.

PMID: 36599902 Free PMC article.

Previous studies have shown the promising role of hesperidin (HSP) as an antioxidant agent against various models of toxic agents. The protective effect of the HSP against CYP-induced parotid damage was evaluated in this study. ...

11

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Molecular docking study of various Enterovirus-A71 3C protease proteins and their potential inhibitors.

Le TTV, Do PC.

Front Microbiol. 2022 Sep 29;13:987801. doi: 10.3389/fmicb.2022.987801. eCollection 2022.

PMID: 36246267 Free PMC article.

Hand, foot, and mouth disease (HFMD) is a common infection that primarily affects children in preschool and kindergarten; however, there is yet no vaccination or therapy available. ...Furthermore, the mutation at E71A has the most significant impact on the docking results …

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The Protective Efficacy of Hesperidin and Thymol on Radiation-Induced Submandibular Gland Damage.

Sakat MS, Kılıç K, Sahin A, Kiziltunc Ozmen H, Yıldırım S, Egilmez E.

Laryngoscope. 2023 Aug;133(8):1885-1892. doi: 10.1002/lary.30405. Epub 2022 Sep 23.

PMID: 36149936

Group 1 represented the control group. Group 2 was regarded as hesperidin Group, and the rats received only hesperidin. Group 3 was regarded as thymol Group, and the rats received only thymol. Group 4 was regarded as a Radiotherapy Group, and the rats were exposed t …

13

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Anticancer Activities of Hesperidin via Suppression of Up-Regulated Programmed Death-Ligand 1 Expression in Oral Cancer Cells.

Wudtiwai B, Makeudom A, Krisanaprakornkit S, Pothacharoen P, Kongtawelert P.

Molecules. 2021 Sep 2;26(17):5345. doi: 10.3390/molecules26175345.

PMID: 34500779 Free PMC article.

Moreover, hesperidin also significantly decreased the viability, proliferation, migration, and invasion of both cell lines. ...The findings of this study support the use of hesperidin as a potential adjunctive treatment for oral cancer....

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Hesperidin reduces dentin wear after erosion and erosion/abrasion cycling in vitro.

Leal IC, Rabelo CS, Viana ÍEL, Scaramucci T, Santiago SL, Passos VF.

Arch Oral Biol. 2021 Sep;129:105208. doi: 10.1016/j.archoralbio.2021.105208. Epub 2021 Jul 19.

PMID: 34298255

OBJECTIVE: To evaluate the action of hesperidin (HPN) at different concentrations to prevent dentin erosive wear, associated or not to abrasion. ...

15

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Influence of flavonoids on long-term bonding stability on caries-affected dentin.

Dávila-Sánchez A, Gutierrez MF, Bermudez JP, Méndez-Bauer ML, Hilgemberg B, Sauro S, Loguercio AD, Arrais CAG.

Dent Mater. 2020 Sep;36(9):1151-1160. doi: 10.1016/j.dental.2020.05.007. Epub 2020 Jun 30.

PMID: 32620332

Five experimental pre-treatment solutions were created using the following flavonoids: quercetin (QUE); hesperidin (HES); rutin (RUT); naringin (NAR), or proanthocyanidin (PRO). A placebo solution (PLA) with no flavonoids added was also evaluated. ...

16

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Modulating effect of hesperetin on the molecular expression pattern of apoptotic and cell proliferative markers in 7,12-dimethylbenz(a)anthracene-induced oral carcinogenesis.

Babukumar S, Vinothkumar V, Ramachandhiran D.

Arch Physiol Biochem. 2020 Dec;126(5):430-439. doi: 10.1080/13813455.2018.1555600. Epub 2019 Jan 20.

PMID: 30663412

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The effect of active components from citrus fruits on dentin MMPs.

Liu Z, Li F, Zhang L, Yu H, Yu F, Chen J.

Arch Oral Biol. 2017 Nov;83:111-117. doi: 10.1016/j.archoralbio.2017.07.006. Epub 2017 Jul 20.

PMID: 28753501

OBJECTIVES: This study was aimed to evaluate the anti-matrix metalloproteinases (MMPs) ability of active components from citrus fruits (hesperetin: Hst, hesperidin: Hsd and naringenin: Nge). METHODS: Inactivation effects of citrus flavonoids (Hst, Hsd, Nge) at different co …

18

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Molecular effects of hesperetin, a citrus flavanone on7,12-dimethylbenz(a)anthracene induced buccal pouch squamous cell carcinoma in golden Syrian hamsters.

Babukumar S, Vinothkumar V, Velu P, Ramachandhiran D, Ramados Nirmal M.

Arch Physiol Biochem. 2017 Oct;123(4):265-278. doi: 10.1080/13813455.2017.1317815. Epub 2017 May 1.

PMID: 28457144

19

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Hesperidin interaction to collagen detected by physico-chemical techniques.

Hiraishi N, Maruno T, Tochio N, Sono R, Otsuki M, Takatsuka T, Tagami J, Kobayashi Y.

Dent Mater. 2017 Jan;33(1):33-42. doi: 10.1016/j.dental.2016.09.035. Epub 2016 Oct 19.

PMID: 27771138

OBJECTIVE: Dentin collagen can be modified by some plant-derived flavonoids to improve properties of dentin organic matrix. Hesperidin (HPN), a hesperetin-7-O-rutinoside flavonoid, has a potential of dentin modification for being based on evidence that a treatment with HPN …

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Effects of Plants on Osteogenic Differentiation and Mineralization of Periodontal Ligament Cells: A Systematic Review.

Costa CR, Amorim BR, de Magalhães P, De Luca Canto G, Acevedo AC, Guerra EN.

Phytother Res. 2016 Apr;30(4):519-31. doi: 10.1002/ptr.5568. Epub 2016 Jan 29.

PMID: 26822584 Review.

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Inhibition of dentine collagen degradation by hesperidin: an in situ study.

van Strijp AJ, Takatsuka T, Sono R, Iijima Y.

Eur J Oral Sci. 2015 Dec;123(6):447-52. doi: 10.1111/eos.12225. Epub 2015 Oct 29.

PMID: 26513330

The aim of this study was to investigate the anti-collagenolytic activity of hesperidin in an in situ model. A single-blind, split-mouth, in situ experiment was designed. ...The results of this in situ study show that hesperidin could play a role in the prese …

22

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Evaluation of Antitumor Activity of Hesperetin-Loaded Nanoparticles Against DMBA-Induced Oral Carcinogenesis Based on Tissue Autofluorescence Spectroscopy and Multivariate Analysis.

Gurushankar K, Nazeer SS, Jayasree RS, Krishnakumar N.

J Fluoresc. 2015 Jul;25(4):931-9. doi: 10.1007/s10895-015-1575-4. Epub 2015 May 7.

PMID: 25948235

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Effect of hesperidin incorporation into a self-etching primer on durability of dentin bond.

Islam MS, Hiraishi N, Nassar M, Yiu C, Otsuki M, Tagami J.

Dent Mater. 2014 Nov;30(11):1205-12. doi: 10.1016/j.dental.2014.08.371. Epub 2014 Sep 5.

PMID: 25194169

METHODS: Experimental primers were prepared by incorporating either 0.5%, 1%, 2%, 5% of hesperidin (HPN) or 0.5% of proanthocyanidins (PA) into Clearfil SE primer. Extracted human molar teeth were restored using the experimental primers or the pure SE primer (control). ...

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In vitro evaluation of plant-derived agents to preserve dentin collagen.

Hiraishi N, Sono R, Sofiqul I, Yiu C, Nakamura H, Otsuki M, Takatsuka T, Tagami J.

Dent Mater. 2013 Oct;29(10):1048-54. doi: 10.1016/j.dental.2013.07.015. Epub 2013 Aug 12.

PMID: 23942145

This study investigated the effect of various plant-derived agents (hesperidin, proanthocyanidin, epigallocatechin gallate and genipin) on the stability of dentin collagen matrix to resist collagenase degradation. ...The greatest reduction in collagen degradation was shown …

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Hesperetin alleviates the inhibitory effects of high glucose on the osteoblastic differentiation of periodontal ligament stem cells.

Kim SY, Lee JY, Park YD, Kang KL, Lee JC, Heo JS.

PLoS One. 2013 Jun 28;8(6):e67504. doi: 10.1371/journal.pone.0067504. Print 2013.

PMID: 23840726 Free PMC article.

Hesperetin (3',5,7-trihydroxy-4-methoxyflavanone) is a metabolite of hesperidin (hesperetin-7-O-rutinoside), which belongs to the flavanone subgroup and is found mainly in citrus fruits. ...

26

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Effect of natural cross-linkers incorporation in a self-etching primer on dentine bond strength.

Islam S, Hiraishi N, Nassar M, Yiu C, Otsuki M, Tagami J.

J Dent. 2012 Dec;40(12):1052-9. doi: 10.1016/j.jdent.2012.08.015. Epub 2012 Sep 11.

PMID: 22982944

METHODS: Flat dentine surfaces were prepared from extracted human molar teeth and were applied with the following self-etching primers. The 0.5% hesperidin (HPN), 0.5% chlorhexidine (CHX) or 0.5% grape seed extract (GSE) was incorporated into Clearfil SE primer (Kuraray Me …

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In vitro effect of hesperidin on root dentin collagen and de/re-mineralization.

Islam SM, Hiraishi N, Nassar M, Sono R, Otsuki M, Takatsura T, Yiu C, Tagami J.

Dent Mater J. 2012;31(3):362-7. doi: 10.4012/dmj.2011-203. Epub 2012 May 14.

PMID: 22673464 Free article.

The aims of this study were to investigate the effects of hesperidin, a citrus flavonoid, on human root dentin demineralization and collagen preservation, and compare it with chlorhexidine and grape seed extract. ...The hesperidin group showed the lowest value in le …

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Effect of hesperidin in vitro on root dentine collagen and demineralization.

Hiraishi N, Sono R, Islam MS, Otsuki M, Tagami J, Takatsuka T.

J Dent. 2011 May;39(5):391-6. doi: 10.1016/j.jdent.2011.03.002. Epub 2011 Mar 21.

PMID: 21414383

The lesion depth and mineral loss were reduced in the lesions where were incubated with hesperidin and chlorhexidine. The remineralization in deep lesions was found when the matrix was incubated in hesperidin, whilst no mineral uptake in deep lesion when incubated i …

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Yoghurt impacts on the excretion of phenolic acids derived from colonic breakdown of orange juice flavanones in humans.

Roowi S, Mullen W, Edwards CA, Crozier A.

Mol Nutr Food Res. 2009 May;53 Suppl 1:S68-75. doi: 10.1002/mnfr.200800287.

PMID: 19415668

When the orange juice was ingested with yoghurt excretion fell back markedly to 9.3 +/- 4.4 micromol. This was not due to a difference in mouth to caecum transit time, as measured with breath hydrogen production, though possibly there may have been a slowing of the bulk of …

30

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Bioavailability and metabolism of orange juice flavanones in humans: impact of a full-fat yogurt.

Mullen W, Archeveque MA, Edwards CA, Matsumoto H, Crozier A.

J Agric Food Chem. 2008 Dec 10;56(23):11157-64. doi: 10.1021/jf801974v.

PMID: 19007165

Nor did yogurt have a significant effect on gastric emptying, as determined by plasma paracetamol levels, or on the mouth to cecum transit time of the head of the meal, assessed by measurement of lactulose-derived breath hydrogen. ...

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Inhibition of oral carcinogenesis by citrus flavonoids.

Miller EG, Peacock JJ, Bourland TC, Taylor SE, Wright JM, Patil BS, Miller EG.

Nutr Cancer. 2008;60(1):69-74. doi: 10.1080/01635580701616163.

PMID: 18444138

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Effects of oral administration of different doses of purified micronized flavonoid fraction on microvascular reactivity after ischaemia/reperfusion in the hamster cheek pouch.

Bouskela E, Cyrino FZ, Lerond L.

Br J Pharmacol. 1997 Dec;122(8):1611-6. doi: 10.1038/sj.bjp.0701554.

PMID: 9422805 Free PMC article.

Local ischaemia was obtained by a cuff mounted around the neck of the everted pouch where it leaves the mouth of the hamster. 3. Measurements were performed before ischaemia, at the onset of reperfusion and 10, 20, 30, 45 and 60 min thereafter. ...

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Microvascular reactivity after ischemia/reperfusion in the hamster cheek pouch: beneficial effects of different oral doses of S-5682 (Daflon 500 mg).

Bouskela E, Cyrino FZ, Lerond L.

Angiology. 1997 Jan;48(1):33-7. doi: 10.1177/000331979704800106.

PMID: 8995341

Daflon 500 mg (S-5682) is a purified, micronized flavonoid fraction containing 90% diosmin and 10% hesperidin that is currently used to treat chronic venous insufficiency and hemorrhoidal disease. ...A ninety-minute local ischemia was obtained by a cuff mounted around the …

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Chemoprevention of 4-nitroquinoline 1-oxide-induced oral carcinogenesis by dietary curcumin and hesperidin: comparison with the protective effect of beta-carotene.

Tanaka T, Makita H, Ohnishi M, Hirose Y, Wang A, Mori H, Satoh K, Hara A, Ogawa H.

Cancer Res. 1994 Sep 1;54(17):4653-9.

PMID: 8062259

Starting 1 week after the stop of 4-NQO exposure, the groups given 4-NQO and a basal diet were switched to the diets containing beta-carotene, hesperidin, and curcumin and maintained on these diets for 22 weeks. The other groups consisted of rats given 500 ppm beta-caroten …

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Inhibitory effect of the Ruscus extract and of the flavonoid hesperidine methylchalcone on increased microvascular permeability induced by various agents in the hamster cheek pouch.

Bouskela E, Cyrino FZ, Marcelon G.

J Cardiovasc Pharmacol. 1993 Aug;22(2):225-30. doi: 10.1097/00005344-199308000-00009.

PMID: 7692162

The Ruscus extract and the flavonoid hesperidine methylchalcone (HMC) are used in treatment of venous insufficiency. In the present study, we used the hamster cheek pouch preparation and investigated the effects of these substances on increased microvascular permeability i …

36

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An exponential model for adaptation in taste.

Gent JF.

Sens Processes. 1979 Dec;3(4):303-16.

PMID: 263646 No abstract available.